某儿童医院132例严重药品不良反应分析

Analysis on 132 Cases of Severe Adverse Drug Reactions in a Children’s Hospital

目的:探讨某儿童医院严重药品不良反应(ADR)发生特点和规律,为临床合理用药提供参考。方法:收集该院2017-2019年上报的严重ADR报告,对患儿年龄、性别、给药途径、药品种类等相关因素进行统计分析。结果:132例严重ADR中,男85例(64.39%),女47例(35.61%)。121例严重ADR给药途径为静脉用药,10例为口服给药,1例为喷雾剂。132例严重ADR中抗感染药物占比(47.73%)最高,其次为糖皮质激素(9.09%)、维生素类及营养支持类药物(6.06%)和中药注射剂(6.06%)。132例严重ADR主要累及皮肤及其附件损害,其次为全身性损害。结论:临床应重视儿童严重ADR的监测和报告,尤其是抗感染药物、糖皮质激素、维生素及营养支持类药物和中药注射剂,进一步规范儿童安全合理用药。

Objective:To investigate the characteristics and rules of severe adverse drug reactions(ADR)in a children’s hospital,so as to promote the rational drug use in the clinic.Methods:Severe ADR reported in the hospital from 2017 to 2019 were collected,and related factors such as age,gender,route of administration and drug categories were statistically analyzed.Results:Of the 132 cases of severe ADR,85 cases were males(64.39%)and 47 cases were females(35.61%).The route of administration in 121 cases of severe ADR was intravenous administration,10 cases were oral administration,and 1 case was spray.Among the 132 cases of severe ADR,anti-infective drugs accounted for the highest proportion(47.73%),followed by glucocorticoids(9.09%),vitamins and nutritional support drugs(6.06%),and traditional Chinese medicine injections(6.06%).One hundred and thirty-two cases of severe ADR mainly involved skin and its accessory damage,followed by systemic damage.Conclusion:Clinical attention should be paid to the monitoring and reporting of severe ADR in children,especially anti-infective drugs,glucocorticoids,vitamins and nutritional support drugs and traditional Chinese medicine injections,so as to further standardize the safe and rational drug use in children.