创伤性异位骨化的研究进展

Research progress of traumatic heterotopic ossification

目的对创伤性异位骨化(heterotopic ossification,HO)的研究进展进行综述。方法广泛查阅国内外关于创伤性HO的相关文献,对其病因、发病机制、病理进展、诊断、预防和治疗等方面进行总结。结果创伤性HO常由关节手术、爆炸伤、神经损伤和烧伤等严重创伤所致。目前广泛认为创伤性HO的发生与组织的炎症反应、低氧等密切相关,口服非甾体抗炎药和手术切除是防治创伤性HO的主要手段。结论当前创伤性HO的发病机制尚不明确,相关预防和治疗措施有效率低,缺乏特异性治疗手段。未来还需要进一步研究创伤性HO的发病机制,寻找特异性的防治靶点。

Objective To review and evaluate the research progress of traumatic heterotopic ossification(HO).Methods The domestic and foreign related research literature on traumatic HO was widely consulted,and its etiology,pathogenesis,pathological progress,diagnosis,prevention,and treatment were summarized.Results Traumatic HO is often caused by severe trauma such as joint operation,explosion injury,nerve injury,and burn.At present,it is widely believed that the occurrence of traumatic HO is closely related to inflammation and hypoxia.Oral non-steroidal antiinflammatory drugs and surgery are the main methods to prevent and treat traumatic HO.Conclusion Nowadays,the pathogenesis of traumatic HO is still unclear,the efficiency of relevant prevention and treatment measures is low,and there is a lack of specific treatment method.In the future,it is necessary to further study the pathogenesis of traumatic HO and find specific prevention and treatment targets.