支气管扩张症微生物感染的研究进展

Research progress on microbial infection in bronchiectasis

支气管扩张症发病率逐年增高,其发病及进展机制目前尚未完全明确。传统的痰液微生物检查对支气管扩张症感染诊断的意义有限。肺组织细菌菌群16S核糖体RNA(16S rRNA)测序分析、长度多态片段聚合酶链反应(LH-PCR)分析等检测方法的出现推翻了既往“下呼吸道通常是无菌的”这种观点,这些分子生物学检测方法有助于更好地识别相关的潜在致病菌。本文对支气管扩张症中肺部微生物组的最新研究进展进行综述。

Bronchiectasis has an increasing incidence worldwide,but its pathogenesis and molecular mechanism remain unclear,and the traditional sputum microbiological examination is of limited significance in diagnosing the disease.With the emergence of various detection methods,such as 16S rRNA pyrosequencing and analysis of bacterial flora in lung tissues,and length polymorphism polymerase chain reaction analysis,the idea that the lower respiratory tract is usually sterile has been nullified,which helps us better identify related potential pathogens.This review discusses the latest research progress on the lung microbiome in bronchiectasis.