尿毒症心肌病发病机制的新进展

New progress in the pathogenesis of uremic cardiomyopathy

尿毒症心肌病是慢性肾脏病常见的心血管并发症之一,是导致尿毒症患者病死率增高的重要原因。尿毒症心肌病主要表现为左心室肥厚、心脏纤维化、心脏收缩和/或舒张功能障碍。尿毒症心肌病发病机制复杂,目前尚未完全阐明。文章从非传统心血管危险因素角度,综述了近年来尿毒症心肌病发病机制的新进展,并且介绍了本课题组最新的研究结果,为尿毒症心肌病的发病机制研究提供新的可能切入点。

Uremia cardiomyopathy,the most important direct cause of death in end stage kidney disease patients,is one of the important cardiovascular complications of chronic kidney disease.Uremia cardiomyopathy is characterized by left ventricular hypertrophy,fibrosis,systolic and/or diastolic dysfunction.The pathogenesis of uremia cardiomyopathy is complex and has not been fully elucidated.This article reviews the recent advances in the pathogenesis of uremia cardiomyopathy from the perspectives of nontraditional cardiovascular risk factors.In addition,we introduce our latest results,and provide a new possible entry point for the research of pathogenesis of uremia cardiomyopathy.