间充质干细胞外泌体的生物学功能及其治疗支气管肺发育不良研究进展

Biological function of mesenchymal stem cell exosomes and advances in treatment of bronchopulmonary dysplasia

支气管肺发育不良是极低出生体重儿常见的慢性肺病,缺乏有效的治疗手段。间充质干细胞因其具有免疫调节、抗炎、促再生等特性为支气管肺发育不良提供了一种新的治疗思路。动物研究显示,间充质干细胞治疗支气管肺发育不良有一定效果,且目前已进入临床试验阶段。基础研究发现间充质干细胞主要通过旁分泌的方式发挥作用,间充质干细胞外泌体是间充质干细胞分泌组中生理相关且功能强大的组成部分。因此文章对间充质干细胞胞外泌体的生物学功能及其治疗支气管肺发育不良的进展作一综述。

Bronchopulmonary dysplasia is a common chronic lung disease in very low birth weight infants and lacks effective treatments.Mesenchymal stem cells(MSC)provide a new treatment for bronchopulmonary dysplasia due to their characteristics of immunoregulation,anti-inflammatory,and promotion of regeneration.Animal studies have shown that MSC are effective in the treatment of bronchopulmonary dysplasia,and it has entered the clinical trial stage.Basic research found that mesenchymal stem cells mainly play a role through paracrine,and mesenchymal stem cell-derived exosomes are a physiologically relevant and powerful component of the MSC secretion group.Therefore,this paper reviews the biological functions of mesenchymal stem cell-derived exosomes and their progress in the treatment of bronchopulmonary dysplasia.