针灸治疗女性腹泻型肠易激综合征的临床疗效观察及对血清丙二醛、总抗氧化能力的调节作用

Clinical Efficacy of Acupuncture and Moxibustion in Treatment of Female Patients with IBS-D and the Regulatory Effect on Serum MDA and T-AOC

目的:观察针灸治疗女性腹泻型肠易激综合征(IBS-D)患者的临床疗效及对血清丙二醛(MDA)、总抗氧化能力(T-AOC)的调节作用。方法:选取2018年10月至2021年1月上海中医药大学附属岳阳中西医结合医院及上海市针灸经络研究所收治的女性IBS-D患者86例作为研究对象,随机分为温针灸组和电针组,每组43例。2组患者均取双侧天枢、上巨虚、三阴交穴,分别行温针灸或电针治疗,每周3次,共治疗4周。观察治疗前后2组患者伯明翰症状量表、IBS症状量表、肠易激综合征患者专用生命质量量表、汉密尔顿焦虑及抑郁量表评分变化情况,以评估2组临床疗效,并检测血清MDA、T-AOC水平变化。结果:治疗后2组临床症状积分、汉密尔顿焦虑及抑郁量表评分均显著降低(P<0.001),肠易激综合征患者专用生命质量量表评分显著增加(P<0.001)。温针灸组与电针组女性IBS-D患者血清MDA水平均显著降低,血清T-AOC水平均显著升高(P<0.01)。结论:温针灸和电针治疗女性IBS-D患者均具有较好的临床疗效,可显著改善患者的生命质量及焦虑抑郁水平,并能调节血清氧化应激相关指标MDA、T-AOC表达水平。

Objective:To observe the clinical efficacy of acupuncture and moxibustion in treating female patients with diarrhea-predominant irritable bowel syndrome(IBS-D)and explore the regulatory effect on serum MDA and T-AOC.Methods:Eighty-six female patients with IBS-D admitted to Yueyang Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai University of Traditional Chinese Medicine and Shanghai Research Institute of Acupuncture and Meridian from October 2018 to January 2021 were randomly divided into a warm needle moxibustion group(n=43)and an electro-acupuncture(EA)group(n=43).The patients received warm needle moxibustion therapy or EA therapy at bilateral“Tianshu”(ST 25),“Shangjuxu”(ST 37),and“Sanyinjiao”(SP 6)in both groups,three times a week,four weeks in total.The clinical efficacies of the two groups were evaluated according to the pre-and post-treatment scores of Birmingham IBS Symptom Questionnaire,IBS Symptom Severity Scale,Irritable Bowel Syndrome Quality of Life Instrument(IBS-QOL),Hamilton Depression Rating Scale(HAMD),and Hamilton Anxiety Rating Scale(HAMA),and the serum levels of MDA and T-AOC were detected.Results:After treatment,the scores of clinical syndrome scale,HAMD,and HAMA in the two groups decreased(P<0.001),and the score of IBS-QOL increased(P<0.001).The warm needle moxibustion group and the EA group showed reduced serum MDA level and increased serum T-AOC level in female patients with IBS-D(P<0.01).Conclusion:Acupuncture and moxibustion can achieve good clinical efficacies in the treatment of female patients with IBS-D,which can significantly improve the quality of life and relieve depression and anxiety of patients,and can regulate the expression levels of oxidative stress-related indicators MDA and T-AOC in the serum.