拉贝洛尔、酚妥拉明联合硫酸镁治疗早发型重度子痫前期的疗效

Effect of Labetalol and Phentolamine Combined with Magnesium Sulfate on Early Onset Severe Preeclampsia

目的:观察拉贝洛尔、酚妥拉明联合硫酸镁治疗早发型重度子痫前期(EOSP)的疗效。方法:选取泉州市中医院2017年12月至2020年12月期间接收的82例EOSP患者,基于患者意愿给予不同治疗方案分为对照组与观察组,各41例。其中对照组给予酚妥拉明联合硫酸镁治疗,观察组在对照组的基础上给予拉贝洛尔治疗,观察比较两组患者分娩结局以及治疗前后血压状况〔舒张压(DBP)、收缩压(SBP)〕、凝血指标〔纤维蛋白原(FIB)、D–二聚体(D–D)、凝血活酶时间(TT)、凝血酶原时间(PT)〕。结果:治疗前两组患者的DBP、SBP比较,差异无统计学意义(P>0.05);治疗后观察组患者的SBP、DBP低于对照组,差异具有统计学意义(P<0.05)。治疗前两组患者的PT、TT、FIB、D–D比较,差异无统计学意义(P>0.05);治疗后观察组患者的PT、TT高于对照组,FIB、D–D低于对照组,差异具有统计学意义(P<0.05)。观察组的新生儿窒息率、产后出血率、剖宫产率均低于对照组,差异具有统计学意义(P<0.05)。结论:拉贝洛尔、酚妥拉明联合硫酸镁治疗EOSP患者时,可下调血压,改善凝血功能,减少不良分娩结局发生率。

Objective To observe the efficacy of labetalol and phentolamine combined with magnesium sulfate in the treatment of early onset severe preeclampsia (EOSP).Methods A total of 82 patients with EOSP admitted to Quanzhou Hospital of Traditional Chinese Medicine from December 2017 to December 2020 were selected,and they were divided into control group and observation group based on patients’ wishes,with 41 cases in each group.The control group was treated with phentolamine combined with magnesium sulfate,and the observation group was treated with labetalol on the basis of the control group.Delivery outcome,[blood pressure (DBP,SBP)],coagulation indexes[FIB,D-Dimer (D-D),thrombin time (TT),prothrombin time (PT)]before and after treatment in the two groups were observed and compared.Results There were no significant differences in diastolic blood pressure (DBP) and systolic blood pressure (SBP) between the two groups before treatment (P > 0.05).After treatment,SBP and DBP in the observation group were lower than those in the control group,the differences were statistically significant (P < 0.05).After treatment,prothrombin time (PT) and thrombin time (TT) in the observation group were higher than those in the control group,while fibrinogen (FIB) and D–Dimer (D-D) were lower than those in the control group,the differences were statistically significant (P < 0.05).The rates of neonatal asphyxia,postpartum hemorrhage and cesarean section in the observation group were lower than those in the control group,with statistical significance (P < 0.05).Conclusion Labetalol and phentolamine combined with magnesium sulfate can reduce blood pressure,improve coagulation function and reduce the incidence of adverse delivery outcomes in PATIENTS with EOSP.