阿仑膦酸钠联合替勃龙治疗绝经后骨质疏松症的效果

Effect of Alendronate Combined with Tibolone on Postmenopausal Osteoporosis

目的:探讨阿仑膦酸钠联合替勃龙治疗绝经后骨质疏松症(PMO)的效果及对骨碱性磷酸酶(BALP),Ⅰ型胶原交联C端肽(β–CTX),25–羟维生素D3〔25(OH)D3〕、雌二醇(E2)水平的影响。方法:选取泉州市正骨医院2020年3月至2021年1月期间收治的118例PMO患者,按照计算机分组法将其分为单药组(阿仑膦酸钠治疗)和联合组(单药组基础上加用替勃龙治疗),各59例。观察两组患者临床疗效和骨代谢情况。结果:联合组患者治疗总有效率为93.22 %,高于单药组的79.66 %,差异具有统计学意义(P<0.05);治疗后联合组患者的25(OH)D3、E2水平高于单药组,BALP、β–CTX水平低于单药组,差异具有统计学意义(P<0.05)。结论:阿仑膦酸钠联合替勃龙治疗PMO能改善患者骨代谢,提高临床疗效。

Objective To investigate the effect of alendronate combined with tibolone in the treatment of postmenopausal osteoporosis (PMO) and its effect on bone alkaline phosphatase (BALP),cross-linked C-terminal peptide of type I collagen(β-CTX),25–hydroxyvitamin D3[25 (OH) D3]and estradiol (E2).Methods 118 patients with PMO treated in Quanzhou Orthopaedic-Traumatological Hospital from March 2020 to January 2021 were divided into single drug group (alendronate treatment) and combined group (single drug group plus tibolone treatment),with 59 cases in each group.The clinical efficacy and bone metabolism of the two groups were observed.Results The total effective rate in the combined group was 93.22%,higher than 79.66% in the single drug group (P < 0.05);after treatment,the levels of 25 (OH) D3 and E2 in the combined group were higher than those in the single drug group,the levels of BALP and β-CTX were significantly lower than those in the single drug group (P < 0.05).Conclusion Alendronate combined with tibolone in the treatment of PMO can improve bone metabolism and clinical efficacy.