血清Hcy、AFP联合CA199检测在肝癌诊断中的价值研究

The Value of Serum Hcy and AFP Combined with CA199 Detection in the Diagnosis of Hepatocellular Carcinoma

目的:探讨血清同型半胱氨酸(Hcy)、甲胎蛋白(AFP)联合糖类抗原199(CA199)检测在原发性肝癌(PHC)诊断中的价值。方法:选取2017年5月至2019年6月广州医科大学附属脑科医院收治的52例PHC患者(PHC组)、68例良性肝病患者(良性肝病组)及同期体检的90例健康人群(对照组)作为研究对象,检测三组研究对象的血清Hcy、AFP、CA199,观察各指标的检测结果,并计算各指标单一、联合检测的诊断效能。结果:PHC组患者血清Hcy、AFP、CA199均明显高于良性肝病组和对照组,且良性肝病组患者的Hcy、AFP、CA199也均明显高于对照组,差异均具有统计学意义(P<0.05);联合检测的灵敏度、特异度、准确度、阳性预测值、阴性预测值均明显高于Hcy、AFP、CA199单一指标诊断,差异均具有统计学意义(P<0.05)。结论:Hcy、AFP、CA199在PHC患者血清中的水平明显高于良性肝病患者与健康人,Hcy、AFP联合CA199检测的诊断效能明显高于单一指标检测。

Objective To investigate the value of serum homocysteine(Hcy),alpha-fetoprotein(AFP)combined with carbohydrate antigen 199(CA199)detection in the diagnosis of primary hepatocellular carcinoma(PHC).Methods A total of 52 patients with PHC group,68 patients with benign liver disease(benign liver disease group)and 90 healthy people(control group)who underwent physical examination during the same period(control group)from May 2017 to June 2019 in the Affiliated Brain Hospital of Guangzhou Medical University were selected as research subjects.Serum Hcy,AFP and CA199 of the three groups were detected.The detection results of each index were observed,and the diagnostic efficacy of single and combined detection of each index was calculated.Results Serum Hcy,AFP and CA199 in PHC group were significantly higher than those in benign liver disease group and control group,and Hcy,AFP and CA199 in benign liver disease group were also significantly higher than those in control group,the differences were statistically significant(P<0.05).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of combined detection were significantly higher than those of Hcy,AFP and CA199,with statistical significance(P<0.05).Conclusion The levels of Hcy,AFP and CA199 in serum of PHC patients were significantly higher than those of benign liver disease patients and healthy people,the diagnostic efficacy of Hcy and AFP combined with CA199 was significantly higher than that of single index.