猴头菌提取物颗粒联合三联疗法对Hp相关性胃病患儿营养状态的影响

Effects of Hericium Extract Granule Combined with Triple Therapy on Hp Associated Gastropathy of Children Nutritional Status

目的:探讨猴头菌提取物颗粒联合三联疗法对幽门螺杆菌(Hp)相关性胃病患儿营养状态的影响。方法:选取惠州市第一妇幼保健院2019年4月至2021年4月期间收治的100例Hp相关性胃病患儿,按照随机数字表法分为对照组与观察组,各50例。对照组采用三联疗法治疗,观察组在三联疗法基础上采用猴头菌提取物治疗,观察两组营养状态、炎症水平。结果:治疗前两组患儿的铁蛋白(SF)、前白蛋白(PA)、血红蛋白(Hb)、白蛋白(ALB)比较,差异无统计学意义(P>0.05);治疗后观察组患儿的SF、PA、Hb、ALB水平均高于对照组,差异具有统计学意义(P<0.05)。治疗前两组患儿的肿瘤坏死因子–α(TNF–α)、C反应蛋白(CRP)、白细胞介素–6、白细胞介素–8比较,差异无统计学意义(P>0.05);治疗后观察组患儿的TNF–α、CRP、白细胞介素–6、白细胞介素–8均低于对照组,差异具有统计学意义(P<0.05)。结论:猴头菌提取物颗粒联合三联疗法用于Hp相关性胃病患儿可有效降低炎症因子水平,改善营养状态。

Objective To investigate the effects of hericium extract granule combined with triple therapy on nutritional status of helicobacter pylori (Hp) associated gastropathy in children.Methods A total of 100 children with HP related gastropathy admitted to the First Maternity and Child Health Hospital of Huizhou from April 2019 to April 2021 were selected and divided into control group and observation group according to random number table method,with 50 children in each group.The control group was treated with triple therapy,and the observation group was treated with hericium hericium extract on the basis of triple therapy,and the nutritional status and inflammation levels of the two groups were observed.Results There was no significant differences in the levels of ferritin (SF),prealbumin (PA),hemoglobin (Hb) and albumin (ALB) between the two groups before treatment(P > 0.05).After treatment,the levels of SF,PA,Hb and ALB in observation group were higher than those in control group,the differences were statistically significant (P < 0.05).There was no significant difference in tumor necrosis factor-α (TNF-α),C-reactive protein (CRP),interleukin-6 and interleukin-8 between the two groups before treatment (P > 0.05).After treatment,the levels of TNF-α,CRP,interleukin-6 and interleukin-8 in observation group were lower than those in control group,the differences were statistically significant (P < 0.05).Conclusion Hericium extract granules combined with triple therapy can effectively reduce the level of inflammatory factors and improve nutritional status in children with HP associated gastropathy.