Prevalence of focal lamina cribrosa defects in eyes with pachychoroid disease spectrum

AIM:To determine the prevalence of focal lamina cribrosa(LC)defect among patients with pachychoroid disease spectrum(PDS)in the absence of peripapillary retinoschisis.METHODS:This retrospective,cross-sectional study comprised of 180 patients with PDS,including polypoidal choroidal vasculopathy(PCV),central serous chorioretinopathy,and pachychoroidal neovasculopathy.Medical records and optic ner ve head evaluations conducted using spectral-domain optical coherence tomography with enhanced depth imaging were reviewed.As a control group,236 patients who underwent ophthalmologic evaluation for vitreous floaters,without obvious ocular disease,were also included.RESULTS:The mean age of the PDS group,which included 118 male patients(65.6%),was 57.4±11.1 y.There was no significant difference between the two groups in age(P=0.710)or sex(P=0.248).Six patients(3.3%)in the PDS group and none in the control group showed focal LC defect(P=0.318).Among the six patients with focal LC defect in the PDS group,four eyes had PCV,one eye was the fellow eye of a PCV eye,and one eye had pachychoroidal neovasculopathy.CONCLUSION:Focal LC defect can be defected in patients with PDS in the absence of peripapillar y retinoschisis.However,the prevalence of focal LC defect was not different significantly between PDS patients and those who did not have PDS.