基于表面增强拉曼光谱检测双酚A的研究进展

Research progress of the detection of bisphenol A based on surface enhanced Raman spectroscopy

双酚A(bisphenolA,BPA)的化学结构与内源性雌激素类似,能模仿或干扰内源性雌激素,发挥拟雌激素作用,是一种典型的环境内分泌干扰物(endocrine disrupting chemicals,EDCs)。表面增强拉曼光谱(surface enhanced Raman spectroscopy,SERS)现已成为单分子水平上最通用的定量检测方法之一,其具有快速、灵敏和无损的分析能力,在BPA分析领域有巨大的应用潜力。本文总结了SERS技术在BPA检测方面的概况,阐述了近年来金、银纳米粒子作为拉曼基底,并联用其他现代分析技术的最新研究成果,主要包括修饰与未修饰基底的传感器,其中修饰基底的传感器分为核酸适配体与SERS联用、分子印迹与SERS联用、免疫分析与SERS联用、分子修饰与SERS联用以及新型柔性材料与SERS联用,以期为进一步合理设计高性能的SERS纳米材料提供指导。

Bisphenol A(BPA)has a chemical structure similar to endogenous estrogen,can mimic or interfere with endogenous estrogen,and is a typical environmental endocrine disruptor(EDCs).Surface enhanced Raman spectroscopy(SERS)has become one of the most common quantitative detection methods at the single molecule level,which has the ability of rapid,sensitive and nondestructive analysis,and has great application potential in the field of BPA analysis.This paper summarized the overview of SERS technology in the detection of BPA,and described the recent research results of gold and silver nanoparticles as Raman substrates and other modern analytical techniques,mainly including modified and unmodified substrate sensors,the modified substrate sensors were divided into nucleic acid aptamer coupled with SERS,molecular blotting coupled with SERS,immunoassay coupled with SERS,molecular SERS,immunoassay and SERS,molecular modification and SERS,and novel flexible materials and SERS,so order to provide guidance for further reasonable design of high-powered SERS nanomaterials.