谷红注射液治疗缺血性脑卒中患者应激性肝损害

Guhong Injection in the treatment of hepatic stress injury in patients with ischemic stroke

目的探讨谷红注射液改善缺血性脑卒中应激性肝损害患者的临床症状及其保护作用与机制。方法本研究是一项随机、双盲对照试验,选取2019年1月~2019年12月成都中医药大学附属医院和成都中医药大学附属四川省康复医院收治的80例脑缺血诱发肝损伤的患者随机分为对照组(乙酰谷酰胺氯化钠注射液治疗,n=40)和谷红治疗组(谷红注射液治疗,n=40)。监测谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBiL),以及血清肿瘤坏死因子(TNF-α)、白介素-6(IL-6)和超氧化物歧化酶(SOD)、丙二醛(MDA)的水平,监测时间点为使用药物前、10 d及20 d。结果治疗前,两组ALT、AST、ALP、TBiL和TNF-α、IL-6、SOD、MDA水平比较,差异均无统计学意义(P>0.05)。治疗后10、20 d,谷红治疗组ALT、AST、ALP、TBiL和TNF-α、IL-6、MDA水平低于对照组,SOD水平高于对照组,差异均有统计学意义(P<0.05)。结论谷红注射液可有效改善缺血性脑卒中应激性肝损害患者的临床症状,谷红注射液的成分红花可能对肝损伤有一定的肝脏保护作用和抗氧化作用。

Objective To investigate whether Guhong Injection improved the clinical symptoms of patients with Hepatic stress injury induced by ischemic stroke and explore the protective effects of Guhong Injection on cerebral ischemia-induced liver damage and its mechanism.Methods This was a randomized,double blind controlled trial.Patients of cerebral ischemia-induced liver damage were randomly divided into the two groups,conventional treatment(n=40)and Guhong Injection treatment(n=40).Alanine aminotransferase(ALT),aspartate transaminase(AST),alkaline phosphatase(ALP)and serum bilirubin level(TBiL)were measured on the baseline and at day 10 and 20 following treatment,at the same time,Serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and mitochondrial superoxide dismutase(SOD),malondialdehyde(MDA)were measured too.Results ALT,AST,ALP,TBiL and TNF-α,IL-6,SOD,MDA in the GH group were no statistically significant difference than in the CG group on the baseline(P>0.05).The level of ALT,AST,ALP,TBiL and TNF-α,IL-6,MDA in the GH group were lower than those in the CG groups,while the level of SOD in the GH group was higher than that in the CG group at day 10 and 20,and the differences were statistically significant(P<0.05).Conclusion Guhong Injection seems to be an efficient method that can improve the clinical symptoms of patients with Hepatic stress injury induced by ischemic stroke.Carthamus tinctorius L.of Guhong Injection may have hepatoprotective effects and anti-oxidant activity in liver injury.