特发性正常压力脑积水的放射影像学研究进展

Advances in Radiographic Studies of Idiopathic Normal Pressure Hydrocephalus

特发性正常压力脑积水(iNPH)是一组以步态障碍、认知障碍和膀胱功能障碍为三联征表现的临床综合征。经脑脊液分流手术后,iNPH的临床症状可得到不同程度的改善,因而该病被认为是一种可治性痴呆。随着研究者们对该病的进一步探索,iNPH的放射影像学相关研究有了新的进展。本研究从脑室扩大的评估、脑网络变化和脑白质纤维变化这三个方面对iNPH的放射影像学研究现状进行综述。

Idiopathic normal pressure hydrocephalus(iNPH)is a clinical syndrome characterized by triad of gait disturbance,cognitive impairment,and urinary incontinence.After cerebrospinal fluid shunt surgery,the clinical symptoms of iNPH can be improved to varying degrees,so the disease is considered to be a treatable dementia.With the further exploration of the disease by researchers,new progress has been made in the studies on radiographic imaging of iNPH.This study reviewed the current status of radiographic researches on iNPH from three aspects:assessment of ventriculomegaly,changes in brain networks,and abnormalities in white matter fibers.