原发性干燥综合征继发肺淀粉样变性影像学表现以及文献复习

Imaging manifestations of pulmonary amyloidosis secondary to primary Sjogren syndrome and literature review

目的 结合回顾文献分析原发性干燥综合征(pSS)继发肺淀粉样变性(PA)的CT及^(18)F-FDG PET/CT表现。方法 回顾性收集4例经病理证实的pSS继发PA患者,均接受胸部CT检查,其中1例接受全身^(18)F-FDG PET/CT检查;结合文献分析pSS继发PA的CT及^(18)F-FDG PET/CT表现。结果 4例胸部CT均表现为双肺多发结节或团块,病灶最大径3~36 mm、中位最大径13 mm, CT值15~410 HU、中位CT值65 HU,部分伴钙化(3/4);并均见肺囊腔样病变(4/4)。^(18)F-FDG PET/CT示部分结节^(18)F-FDG摄取轻度升高。结论 pSS继发PA的CT表现具有一定特征性;结合^(18)F-FDG PET/CT有助于与肿瘤性病变相鉴别。

Objective To analyze imaging manifestations of pulmonary amyloidosis(PA) secondary to primary Sj9 gren syndrome(pSS) combined with literature review. Methods Four patients with PA secondary to pSS confirmed by pathology were retrospectively collected. All patients underwent chest CT examination, and 1 patient underwent whole body ^(18)F-FDG PET/CT. The imaging manifestations of PA secondary to pSS were analyzed combined with literature review. Results Chest CT showed multiple lung nodules or masses in both sides(4/4), with the maximum diameter of 3-36 mm and the median maximum diameter of 13 mm. The CT value of lesions was 15-410 HU, with the median CT value of 65 HU. Some lesions were found accompanied by calcifications(3/4), while cystic lesions(4/4) were found in all 4 cases.^(18)F-FDG PET/CT showed slightly increased ^(18)F-FDG uptake in some nodules. Conclusion CT manifestations of PA secondary to pSS had certain characteristics, which combined with ^(18)F-FDG PET/CT examination were helpful to distinguishing PA from tumor lesions.