吸烟和饮酒的协同作用与恶性肿瘤发生风险的研究进展

Review of the synergistic effects of smoking and drinking consumption on the risk of malignant tumors

我国新发恶性肿瘤病例超过456万,占全球癌症总发病例数的23%,疾病负担严重。吸烟和饮酒是恶性肿瘤明确的重要危险因素,本文通过全面描述吸烟和饮酒对恶性肿瘤发病风险交互作用的近期文献报道,概述吸烟和饮酒对各类恶性肿瘤发病风险的增加存在协同作用,重点总结了针对头颈部恶性肿瘤和食管鳞癌的研究结果,提示戒烟和戒酒有助于降低两类癌症的风险,该领域的研究进展为烟草和酒精这两类常见恶性肿瘤危险因素的预防和控制提供进一步的科学证据。

There are more than 4.56 million new cases of malignant tumors in our country, accounting for 23% of the total number of cases of malignant tumors in the world, and the burden of disease is serious. Smoking and drinking have been identified as the most important risk factors of malignant tumors. This article comprehensively describes recent literature reports on the interaction between smoking and drinking on the risk of malignant tumors, overviews that smoking and drinking have synergistic effects on the increased risk of various malignant tumors, focuses on the results of studies on malignant tumors of the head and neck and esophageal squamous cell carcinoma, and suggests that quitting smoking and alcohol can help reduce the risk of two types of malignant tumors, and the research progress in this field provides further scientific evidence for the prevention and control of two common and important risk factors of malignant tumors, tobacco and alcohol.