铁死亡与生殖系统疾病研究进展

RESEARCH PROGRESS ON IRON DEATH AND DISEASES OF REPRODUCTIVE SYSTEM

铁死亡是一种新的自噬依赖性细胞死亡形式。许多研究发现,铁死亡参与多种疾病的发生发展,例如神经系统退行性疾病、慢性心血管疾病、肿瘤、泌尿系统肾疾病、空肠疾病及呼吸系统疾病等。但在生殖系统,相关研究不多,也不完善。本文系统性回顾铁死亡作用机制相关研究,综述了在生殖系统相关临床疾病中的作用,讨论了铁死亡研究现状、尚未解决的问题及展望未来研究方向,从而使人们更多地认识了解铁死亡,为探讨其介导的疾病的治疗方法打下研究基础。

Ferroptosis is a new autophagy dependent form of cell death.Many studies have found that ferroptosis is involved in the occurrence and development of many diseases,such as neurodegenerative diseases、chronic cardiovascular diseases、tumors、urinary and renal diseases、jejunal diseases and respiratory diseases.But in the reproductive system,the related research is not much and not perfect.In this paper,we systematically review the research on the mechanism of ferroptosis,review the role of ferroptosis in clinical diseases related to reproductive system,discuss the research status,unsolved problems and future research direction of ferroptosis,so as to make people know more about ferroptosis and lay a research foundation for exploring the treatment methods of ferroptosis mediated diseases.