老年静止性腔隙性脑梗死的相关危险因素研究

Study on related risk factors for senile silent lacunar infarction

目的:探讨老年静止性腔隙性脑梗死的相关危险因素。方法:选取某健康管理中心某时期确诊的老年静止性腔隙性脑梗死的体检者687例为研究对象,并选取同时期经头颅CT证实无腔隙性脑梗死的老年体检者173例入组对照组,就其一般情况(性别、年龄)、相关病史(高血压、糖尿病、吸烟史)和相关实验室检查[血尿酸(UA)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)]进行分析,研究其与老年静止性腔隙性脑梗死的相关性。结果:单因素分析:病例组中年龄、高血压、糖尿病、吸烟史、UA、TC、LDL-C均高于对照组,HDL-C病例组低于对照组,两组比较差异有统计学意义(P<0.05);病例组TG水平较对照组稍高,但差异无明显统计学意义(P>0.05);多因素Logistic回归分析发现年龄、高血压、糖尿病、UA、TC、LDL-C为老年静止性腔隙性脑梗死的独立危险因素,HDL-C为老年静止性腔隙性脑梗死的独立保护因素(P<0.05)。结论:年龄、高血压、糖尿病、UA、TC、HDL-C、LDL-C与老年静止性腔隙性脑梗死的发生存在明显相关性;控制高血压、糖尿病,降低TC、LDL-C,适当提高HDL-C水平对于预防老年静止性腔隙性脑梗死的发生有积极的意义。

Objective:To explore the relevant risk factors of senile silent lacunar infarction.Methods:A total of 687 patients diagnosed with elderly senile silent lacunar infarction at a certain period in a physical examination center were selected as the study subjects,And 173 elderly patients confirmed by cranial CT were selected into the control group,Its general conditions(gender,age),related medical history(hypertension,diabetes,smoking)were analyzed to investigate its association with elderly silent lacunar infarction by related laboratory examinations(UA,TC,HDL-C,LDL-C,TG).Results:Univariate analysis:Age,hypertension,diabetes,smoking history,and UA,TC,LDL-C were all higher in the case group than in the control group,The HDL-C case group was lower than controls and the two groups were statistically significant(P<0.05);The TG levels were slightly higher than the controls,but not significant(P>0.05);Multivariate Logistic regression analysis found age,hypertension,diabetes,and UA,TC,LDL-C as independent risk factors for elderly senile silent lacunar infarction,HDL-C is an independent protective factor for elderly senile silent lacunar infarction(P<0.05).Conclusion:Age,hypertension,diabetes,UA,TC,HDL-C,LDL-C and the occurrence of elderly senile silent lacunar infarction have an obvious correlation;Controlling hypertension,diabetes and reducing TC,LDL-C,and appropriately increasing HDL-C levels have positive significance for preventing the occurrence of senile silent lacunar infarction in old age.