宫腔镜联合腹腔镜子宫肌瘤切除术治疗子宫肌瘤患者的效果

Effects of hysteroscopic combined with laparoscopic myomectomy in treatment of patients with uterine fibroids

目的:观察宫腔镜联合腹腔镜子宫肌瘤切除术治疗子宫肌瘤患者的效果。方法:选取88例子宫肌瘤患者为研究对象,根据随机数字表法分为对照组(n=44)和观察组(n=44)。对照组采用腹腔镜子宫肌瘤切除术治疗,观察组采用宫腔镜联合腹腔镜子宫肌瘤切除术治疗,比较两组围术期指标[术中出血量、手术时间、肛门排气时间、住院时间]水平、手术前后血清炎性因子[C反应蛋白(CRP)、白细胞介素(IL)-8、IL-6、肿瘤坏死因子-α(TNF-α)]水平和术后3个月并发症发生率。结果:观察组手术时间、住院时间和肛门排气时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05);术后,两组血清CRP、IL-6、IL-8和TNF-α水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为2.27%(1/44),低于对照组的18.18%(8/44),差异有统计学意义(P<0.05)。结论:宫腔镜联合腹腔镜子宫肌瘤切除术治疗子宫肌瘤患者可改善围术期指标水平,降低血清炎性因子水平和并发症发生率,效果优于单纯腹腔镜子宫肌瘤切除术治疗。

Objective:To observe effects of hysteroscopic combined with laparoscopic myomectomy in treatment of patients with uterine fibroids.Methods:88 patients with uterine fibroids were selected as the research objects and were divided into control group(n=44)and observation group(n=44)by using the random number table method.The control group was treated with laparoscopic myomectomy,while the observation group was treated with hysteroscopic combined with laparoscopic myomectomy.The levels of perioperative indicators[intraoperative blood loss,operation time,anal exhaust time,hospitalization time],the serum inflammatory factor levels[C-reactive protein(CRP),interleukin(IL)-8,IL-6,tumor necrosis factor-α(TNF-α)]before and after the surgery and 3-month postoperative complication rate were compared between the two groups.Results:The operation time,the hospitalization time and the anal exhaust time of the observation group were shorter than those of the control group;the intraoperative blood loss was less than that of the control group;and the differences were statistically significant(P<0.05).After the surgery,the levels of serum CRP,IL-6,IL-8 and TNF-αin the two groups were higher than those before the surgery;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of complications in the observation group was 2.27%(1/44),which was lower than 18.18%(8/44)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Hysteroscopic combined with laparoscopic myomectomy for the patients with uterine fibroids can improve the perioperative index indicator levels and reduce the serum inflammatory factor levels and the postoperative complication rates.Moreover,it is superior to single simple laparoscopic myomectomy.