软通道与硬通道微创介入术治疗老年高血压脑出血患者的效果比较

Comparison of effects of soft channel and hard channel minimally invasive interventions in treatment of elderly patients with hypertensive intracerebral hemorrhage

目的:比较软通道与硬通道微创介入术治疗老年高血压脑出血患者的效果。方法:选取100例老年高血压脑出血患者为研究对象,按照随机数字表法分为观察组与对照组各50例。对照组采用硬通道微创介入术治疗,观察组采取软通道微创介入术治疗,比较两组疗效、美国国立卫生研究院卒中量表(NIHSS)评分、神经功能指标[神经生长因子(NGF)、神经元特异性烯醇化酶(NSE)]水平、应激指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、脂质过氧化物(LPO)]水平和并发症发生率。结果:观察组治疗总有效率为96.00%,明显高于对照组的78.00%,差异有统计学意义(P<0.05);出院时,两组NIHSS评分均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05);出院时,两组NGF、NSE水平均高于术前,且观察组高于对照组,差异有统计学意义(P<0.05);术后1 d,两组SOD、GSH-Px、LPO水平均高于术前,但观察组均低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为4.00%,明显低于对照组的20.00%,差异有统计学意义(P<0.05)。结论:软通道微创介入术治疗老年高血压脑出血患者可提高治疗总有效率和神经功能指标水平,以及降低NIHSS评分、应激指标水平和并发症发生率,效果优于硬通道微创介入术。

Objective:To compare effects of soft channel and hard channel minimally invasive interventions in treatment of elderly patients with hypertensive intracerebral hemorrhage.Methods:100 elderly patients with hypertensive cerebral hemorrhage were selected as the research objects,and were divided into observation group and control group according to the random number table method,50 cases in each group.The control group was treated with hard channel minimally invasive interventional therapy,while the observation group was treated with soft channel minimally invasive interventional therapy.The curative effect,the national institutes of health stroke scale(NIHSS)score,the neurological function indicator levels[nerve growth factor(NGF),neuron-specific enolase(NSE)],the stress indicator levels[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),lipid peroxide(LPO)],and the incidence of complications were compared between the two groups.Results:The total effective rate of the observation group was 96.00%,which was significantly higher than the control group of 78.00%,and the difference was statistically significant(P<0.05).At discharge,the NIHSS scores of both groups were lower than those before the surgery;that of the observation group was lower than that of the control group;and the differences were statistically significant(P<0.05).At discharge,the levels of NGF and NSE in both groups were higher than those before the surgery;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05).1 day after the surgery,the levels of SOD,GSH-Px and LPO in the two groups were higher than those before the surgery;however,those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of complications in the observation group was 4.00%,which was significantly lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Soft channel minimally invasive intervention in the treatment of the elderly patients with hypertensive intracerebral hemorrhage can improve the total effective rate of treatment and the levels of neurological function indexes and reduce the NIHSS score,the levels of stress indicators and the incidence of complications.Moreover,it is superior to hard channel minimally invasive interventional therapy.