长链非编码RNA在阿尔茨海默病中的研究进展

Research progress on lncRNAs in Alzheimer’s disease

阿尔茨海默病(Alzheimer's disease,AD)是常见的神经退行性疾病,也是最为常见的一类老年痴呆类型。AD主要的病理变化包括淀粉样蛋白(amyloid-β,Aβ)沉积、tau蛋白过度磷酸化、胆碱能神经元的缺失、神经炎症以及代谢障碍等。然而,有关AD具体的发病机制和分子谱尚不清楚,这给AD的诊断和治疗带来很大的挑战。越来越多的研究发现,长链非编码RNA(long non-coding RNAs,lncRNAs)在AD发病机制中发挥着重要作用。本文就lncRNAs在AD的研究进展,从lncRNAs通过影响Aβ聚积、突触功能、炎症反应和线粒体功能等方面参与AD的发病来展开综述介绍,为AD早期诊断的生物标志物和药物治疗靶点提供新思路。

Alzheimer’s disease(AD)is the common neurodegenerative disease in the center never system and the typical dementia in old people.The major pathological changes of AD are the accumulation of amyloid-β(Aβ)plaques,neurofibri-llary tangles,loss of cholinergic neurons,inflammation and metabolism dysfunction.However,the molecular mechanism leading to AD pathogenesis is not clear.More and more studies reported that long non-coding RNAs(lncRNAs)play important roles in AD.In this review,we briefly introduce the recent research progress on lncRNAs in AD,including their regulation of clearance of the Aβplaques,synaptic function,inflammation reaction and mitochondrial function,and thus providing the references for that lncRNAs can serve as a potential diagnostic biomarker and therapeutic target in AD.