活性塑料瓶盖中抗氧剂的特定迁移与模拟迁移对比研究

Comparison of Mathematical Simulation with Experiment of Antioxidants Migration from Active Plastic Caps into Food Simulants

为了验证抗氧化活性塑料瓶盖的安全性,以及采用迁移模拟软件替代迁移试验的可行性,在高密度聚乙烯(HDPE)中添加丁基羟基茴香醚(BHA)和2,6-二叔丁基对甲酚(BHT)制备抗氧化活性瓶盖。用高效液相色谱(HPLC)法检测瓶盖中抗氧化剂的初始含量,以及两种抗氧化剂在体积分数分别为50%、95%的乙醇作食品模拟液中的特定迁移量;同时利用AKTS-SML软件,分别根据Piringer模型和Brandsch模型的扩散系数,在70℃、2 h和40℃、10 d条件下进行迁移模拟。研究结果表明,该测定方法的加标回收率在78.8%~111.0%之间,相对标准偏差在0.1%~4.0%范围内;瓶盖中的BHA与BHT的实际迁移量均小于模拟迁移量;抗氧化剂的浓度、迁移时间、迁移物质的分子量和体积以及模拟液的极性都会对迁移结果产生较大影响;在抗氧化活性瓶盖安全评估中,用数学模拟代替迁移实验的可行性仍有待进一步研究。

In order to verify the safety of antioxidant active plastic bottle caps and the feasibility of using mathematical simulation to replace migration tests,the antioxidant active caps were prepared by adding butyl hydroxyanisole(BHA)and butylated hydroxytoluene(BHT)to high-density polyethylene(HDPE).The initial content of antioxidants in HDPE antioxidative bottle caps was detected by HPLC.The migration of BHA and BHT from the caps into food simulants 50%ethanol and 95%ethanol was determined.In addition,AKTS-SML software was used to simulate the migration with the diffusion coefficient of Piringer model and Brandsch model respectively under the migration conditions of 70℃/2 h and 40℃/10 d.The results showed that the recovery rate of the detection method was 78.8%~111.0%,and the relative standard deviation was in the range of 0.1%~4.0%.The actual migration amount of BHA and BHT in the bottle cap was less than the simulated migration amount.The concentration of antioxidant,migration time,molecular weight and the polarity of the simulated liquid all had a great influence on the migration results.The feasibility of using mathematical simulation to replace the migration experiment in the safety assessment of the antioxidant active bottle caps remained to be improved.