维生素D对辅助生殖技术助孕结局的影响

Effect of Vitamin D on Outcomes of Assisted Reproduction Technology

维生素D除了作为类固醇激素参与钙磷代谢、维持骨质稳态外,也可作为生殖激素发挥作用。在女性体内,维生素D参与卵泡生成、卵巢性激素的产生,从而影响卵巢储备功能;在男性体内,可影响精液质量和精子活力。维生素D受体在两性生殖器官中广泛表达,可通过多种作用机制影响辅助生殖技术助孕夫妇的生育力及其妊娠结局。然而当前对不孕患者通过辅助生殖技术助孕时,外源性补充维生素D能否改善其妊娠结局的意见尚不统一。综述维生素D对两性生殖功能的影响,并讨论维生素D能否改善辅助生殖技术助孕结局。

Vitamin D not only participates in the calcium and phosphorus metabolism and the skeletal homeostasis as a steroid hormone,but also plays a role as a reproductive hormone.In women,vitamin D is involved in follicular formation and the production of ovarian sex hormones,which affects ovarian reserve function.In men,it can affect semen quality and sperm motility.Vitamin D receptor is widely expressed in the reproductive organs of both sexes,which can affect the fertility and pregnancy outcome of assisted reproductive technology through a variety of mechanisms.However,there is no consensus on whether exogenous vitamin D supplementation improves pregnancy outcomes of infertile patients undergoing assisted reproductive technology.This paper reviews the effect of vitamin D on male and female reproductive function,and discusses whether vitamin D can improve the outcome of assisted reproductive technology.