特立帕肽不良反应分析

Adverse reactions induced by teriparatide

目的分析特立帕肽不良反应的发生规律及特点,为临床安全用药提供参考。方法检索2002年1月1日至2020年3月31日中国知网、维普网、万方数据、中国生物医学文献数据库、PubMed数据库、Embase,收集特立帕肽致不良反应的个案报道并进行统计分析。结果收集17篇文献20例不良反应个案报道,主要涉及肌肉骨骼损害、代谢和营养障碍和皮肤及其附件损害等。大部分不良反应在停药后能够很快痊愈,肌肉骨骼系统损害缓解常需数月甚至伴随终身。结论特立帕肽使用前,医师应掌握患者血钙、血磷、碱性磷酸酶和肌酐等基本生化指标,充分排除骨恶性肿瘤、骨转移及基线骨肉瘤风险增加的患者。

Objective To analyze the patterns and characteristics of adverse reactions induced by teriparatide and to provide guidance for its rational use in clinic.Methods Domestic and foreign journals published between January 1,2002 and March 31,2020 were retrieved to collect data on cases of adverse reaction induced by teriparatide before statistical analysis.Results A total of 20 adverse reactions reported by 17 articles were collected,involving musculo-skeletal system disorders,metabolic and nutritional disorders and skin damage.Most of the adverse reactions were cured soon after discontinuation of medication,but musculo-skeletal system disorders might take months to cure or persist throughout one’s life.Conclusion Before prescribing teriparatide,doctors should find out about the basic biochemical indicators,such as blood calcium,phosphorus,alkaline phosphatase and creatinine and make sure that patients with bone malignant tumors,bone metastases,and at high risk of osteosarcoma are excluded from use.