高强度聚焦超声消融术治疗子宫肌瘤的疗效及对血清VEGF ER水平妊娠结局的影响

Efficacy of High-Intensity Focused Ultrasound Ablation in the Treatment of Uterine Fibroids and Its Influence on Levels of Serum VEGF and ER and Pregnancy Outcomes

目的:研究运用高强度聚焦超声消融术对子宫肌瘤的疗效、血清血管内皮生长因子(VEGF)、雌激素受体(ER)水平及妊娠结局有何影响。方法:选取我院2019年1月至2020年9月收治的121例育龄期子宫肌瘤患者作为研究对象,根据医生建议、患者疾病进展和意愿,将这121例患者分为对照组(n=61例)和观察组(n=60例),对照组采取常规保守药物治疗方法,观察组采取高强度聚焦超声消融术治疗,比较两组患者治疗后的疗效、子宫和子宫肌瘤体积、血清VEGF、ER、雌二醇(E2)水平和术后妊娠情况。结果:实施相应治疗方法前,两组患者子宫和子宫肌瘤体积、血清VEGF、ER、E2水平均无明显差异(P>0.05);治疗后,两组患者子宫和子宫肌瘤体积、血清VEGF、ER、E2水平均有所降低,且观察组治疗前后上述指标水平差值均明显大于对照组(P<0.05)。实施治疗后,观察组患者疗效和妊娠情况均优于对照组(P<0.05)。结论:高强度聚焦超声消融术对子宫肌瘤疗效显著,可以降低患者血清VEGF、ER水平、子宫和子宫肌瘤体积,且效果显著,观察组患者妊娠结局也比对照组好,该种治疗技术有临床推广价值。

Objective:To study the efficacy of high-intensity focused ultrasound ablation on uterine fibroids and its influence on levels of serum vascular endothelial growth factor(VEGF)and estrogen receptor(ER)and pregnancy outcomes.Methods:Totally 121 patients with uterine fibroids of childbearing age admitted to the hospital from January 2019 to September 2020 were selected as the research subjects,and they were divided into control group(n=61)and observation group(n=60)according to the medical advices,progression of disease and patients’desires.The control group was treated with conventional conservative drugs,and the observation group underwent high-intensity focused ultrasound ablation.The efficacy,uterine volume and uterine fibroids volume,levels of serum VEGF,ER and estradiol(E2)and postoperative pregnancy were compared between the two groups after treatment.Results:Before implementing the corresponding treatments,there were no significant differences in the uterine volume,uterine fibroids volume and levels of serum VEGF,ER and E2 between the two groups(P>0.05).After treatment,the uterine volume,uterine fibroids volume and levels of serum VEGF,ER and E2 were decreased in the two groups,and the difference of the above indexes in the observation group before and after treatment was significantly greater than that in the control group(P<0.05).After treatment,the efficacy and postoperative pregnancy of observation group were better than those of control group(P<0.05).Conclusion:High-intensity focused ultrasound ablation has a significant efficacy on uterine fibroids.It can reduce the levels of serum VEGF and ER and the volume of uterus andvolume of uterine fibroids,and it has a significant effect and the pregnancy outcomes of observation group are better than control group.Thus this kind of treatment method has clinical promotion value.