真实世界喜炎平注射液治疗病毒性肠道感染数据挖掘及分析

Data mining and network analysis of Xiyanping injection in the treatment of viral intestinal infection based on the real world

目的对喜炎平注射液治疗病毒性肠道感染的用药特征进行分析,以指导临床合理用药。方法基于中国中医科学院中医临床基础医学研究所构建的医院信息管理系统(HIS)数据库,对29家医院2006年12月1日至2016年6月30日间1 814例使用喜炎平注射液治疗的肠道感染患者进行临床特征和联合用药关联规则分析,采用Tabu搜索算法进行数据处理。结果喜炎平注射液联用西药中用药次数最多的是口服补液盐、复合维生素、西咪替丁类药和抗生素类药;联用中药中用药次数最多的是清热剂、固涩剂和清热解毒剂。结论在病毒性肠道感染治疗中,较推荐的治疗方案是应用喜炎平注射液联合补液、中药固涩剂,达到抗病毒、止泻、调整胃肠道环境。

Objective To analyze the way in which Xiyanping injection is used in the treatment of viral intestinal infections so as to guide clinical rational medication. Methods Based on the hospital information management system(HIS) database constructed by the Institute of Clinical Basic Medicine of Chinese Academy of Traditional Chinese Medicine, the clinical data on 1 814 patients with intestinal infections treated with Xiyanping injection in 29 hospitals between December 1, 2006 and June 30, 2016 was analyzed;and the patterns of combined medications were studied.The data was processed with the Tabu search algorithm. Results The most frequently used western medicine was oral rehydration salt, compound vitamin, cimetidine and antibiotics. The most frequently used traditional Chinese medicine was antipyretic, astringent and antipyretic antidote. Conclusion In the treatment of viral intestinal infections, Xiyanping injection is often combined with vitamins, oral rehydration salt or with antipyretic antidotes and astringents to combat viruses, cure diarrhea, adjust the gastrointestinal environment and provide symptomatic treatment.