小金片致严重肝损伤1例分析

One case of serious liver injury induced by Xiaojin tablets

目的探讨严重肝功能损伤与小金片的相关性。方法通过1例服用小金片导致严重肝损伤的不良反应,分析与小金片的相关性,通过查找文献分析其中药成分及制剂导致不良反应的机制。结果根据《中草药相关肝损伤临床诊疗指南》的RUCAM表,将患者评定为药物性肝损伤,肝细胞损伤型,慢性,RUCAM 8分(很可能),严重程度3级。结论小金片引起的严重肝损伤与患者自身免疫、药品成分、质量标准等有关。

Objective To explore the correlations between serious liver function injury and Xiaojin tablets. Methods The adverse reactions of one case of serious liver injury caused by Xiaojin tablets were analyzed to study the correlation with Xiaojin tablets. The mechanism by which the medicinal ingredients and preparations caused adverse reactions was investigated by searching literature. Results According to the RUCAM table specified in the Guidelines for Clinical Diagnosis and Treatment of Herb-induced Liver Injury, this patient was diagnosed with chronic drug-induced liver cell injury. The RUCAM score was 8(most likely), and the severity level was 3. The side effects of Xiaojin tablets might have been related to the toxic components. Conclusion The serious liver injury caused by Xiaojin tablets is related to the patient’s autoimmunity, drug composition and quality standard.