氟比洛芬酯注射液致急性肝肾功能衰竭1例分析

One case of acute hepatic and renal failure induced by flurbiprofen axetil injection

目的为预防临床应用氟比洛芬酯注射液致肝肾功能损伤提供依据。方法分析1例双膝单髁置换术后患者使用氟比洛芬酯注射液致急性肝肾衰竭的诊治经过,根据国家药品不良反应监测中心制定的药品不良反应(ADR)判定标准进行该例严重ADR的关联性评价。结果停药并给予床旁血液净化联合血液灌流、保肝、抗感染治疗后,患者肝肾功能基本恢复正常。结论临床应用氟比洛芬酯注射液时,除关注患者胃肠道与皮肤过敏等不良发应外,还需密切关注其肝肾功能的变化,同时警惕预示肝肾毒性反应的症状和体征,以确保临床用药在获取疗效的同时兼具安全性。

Objective To provide evidence for clinical use of flurbiprofen axetil injection and to prevent liver and kidney damage. Methods A retrospective view of the process of diagnosis and treatment of one patient was analyzed, who was cured with flurbiprofen axetil injection after unicompartmental knee arthroplasty and then appeared acute hepatic and renal failure. The relevance evaluation of severe adverse reaction was carried according to the ADR criteria established by National ADR Monitoring Center. Results The liver and kidney functions of the patient were restored to normal after the patient was stopped the flurbiprofen axetil injection and treated with blood purification combined with hemoperfusion and some liver protection and anti-infection medicines. Conclusion This case reminds us that in the clinical application of flurbiprofen axetil injection, in addition to paying attention to adverse reactions such as gastrointestinal tract and skin allergies, we also need to pay close attention to changes in liver and kidney function. At the same time, be vigilant for the symptoms and signs that predict liver and kidney toxicity, so as to ensure that clinical medications are effective and safe.