测定健康人群摄入三种口服营养补充剂的血糖生成指数:一项单盲交叉研究

Glycemic Index of Three Oral Nutritional Supplements in Healthy Adults:A Single-Blind Crossover Study

目的:测定健康人群摄入3种口服营养补充剂(ONS)的血糖生成指数(GI)和胰岛素指数(II)。方法:对12名健康成人进行了单盲交叉研究。受试者在每次访视时空腹摄入服用3种受试产品中的1种,2次访视之间有1周的洗脱期。每个受试者都摄入了所有受试产品。3种受试产品分别为两种新开发的ONS(全营养粉1、全营养粉2)以及阳性对照(全营养粉3)。受试者每次摄入相当于含碳水化合物50 g的受试产品,测量餐后15、30、45、60、90、120、180、240 min的血糖和胰岛素水平。用Wolever法计算血糖和胰岛素曲线下面积(AUC),得到3种营养粉剂的GI和II。结果:以葡萄糖的GI、II为参考标准,3种营养粉的GI分别为44、54、29;II分别为163、182、119。结论:两种研发的全营养粉中,全营养粉1更适合作为糖尿病患者的口服营养补充选择。

【Objective】The main objective of this study was to evaluate the glycemic index(GI)and insulin index(II)of three oral nutritional supplements(ONS)in healthy adults.【Method】A single-blind crossover study was conducted in 12 healthy adults.Fasted subjects consumed one of three treatments at each visit,with a one week wash out period between visits.Every subject received all treatments.Treatments included two newly developed ONS(powder 1,powder 2)as well as a positive control(powder 3).Blood glucose and insulin levels at 15,30,45,60,90,120,180 and 240 min were measured after the volunteers consumed one of the treatments which all of containing 50g carbohydrates per serving.The Wolever method was used to compute the area under the curve(AUC)for blood glucose and insulin,and GI and II of three powders were obtained.【Result】Using the GI and II of 50g glucose powder as reference standard,the GI of nutrition powders 1,2 and 3 are 44,54,29,respectively,and the II of nutrition powders 1,2 and 3 are 163,182,119,respectively.【Conclusion】Among the two newly developed ONS formulas,powder 1 is more suitable as an ONS for diabetics.