血清铁蛋白在NASH中的诊断价值

Diagnostic Value of Serum Ferritin in the Non-alcoholic Steatohepatitis

目的探讨血清铁蛋白(serum ferritin,SF)在非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)中的诊断价值。方法回顾性分析2010年4月~2021年5月在笔者医院经肝活检确诊的108例非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者的临床资料。依据病理结果分为NASH组50例和NAFL组58例,分析两组资料间的差异性、NASH发生的危险因素以及SF对NASH的诊断价值。结果NASH组的BMI、ALB、SF水平大于NAFL组(P<0.05)。Logistic回归分析显示SF是NASH发生的独立危险因素(P<0.05)。SF的ROC曲线下面积、截断值、敏感度、特异性、阳性预测值和阴性预测值分别为0.640、438.05ng/ml、40.00%、86.21%、71.43%和62.50%。结论SF可能对NASH具有一定的诊断价值,可作为NASH的一个辅助诊断指标。

Objective To explore the diagnostic value of serum ferritin(SF)in non-alcoholic steatohepatitis(NASH).Methods The clinical data of 108 patients with non-alcoholic fatty liver disease(NAFLD)diagnosed by liver biopsy in our hospital from April 2010 to May 2021 were retrospectively analyzed.According to pathological results,50 patients were divided into NASH group and 58 patients were divided into NAFL group.The differences between the two groups of data,the risk factors of NASH and the diagnostic value of SF for NASH were analyzed.Results BMI,ALB and SF in NASH group were higher than those in NAFL group(P<0.05).Logistic regression analysis showed that SF were independent risk factors for NASH(P<0.05).The area under ROC curve、cut-off value、sensitivity、specificity、positive predictive value and negative predictive value of SF were 0.640,438.05ng/ml,40.00%,86.21%,71.43%,62.50%.Conclusion SF may have certain diagnostic value for NASH and can be used as an auxiliary diagnostic index for NASH.