间充质干细胞发挥抗菌作用的机制研究进展

Research Progress in the Mechanisms Underlying the Antibacterial Action of Mesenchymal Stem Cells

对抗菌药物具有强耐药性的“超级细菌”对人和家畜健康造成巨大威胁。广泛、高频使用种类有限的抗菌药物治疗人、家畜以及宠物细菌感染性疾病是产生“超级细菌”的根源。寻找现有常规抗菌药物的替代品或增强剂是当前热点研究方向之一。研究表明,间充质干细胞(mesenchymal stem cells,MSCs)具有抗菌特性。理论上,MSCs有可能成为治疗细菌感染性疾病的有效手段。对MSCs影响细菌存活的作用机制以及抗菌药物可能对MSCs功能产生的影响等方面的研究进展进行综述,以期为进一步阐明MSCs抗菌作用机制、挖掘MSCs作为治疗细菌感染性疾病新方法的潜力提供参考。

The emergence of ′superbug′ with high antimicrobial resistance poses a serious threat to human and domestic animal health. The fundamental cause of ′superbug′ is extensive and high-frequency usage of limited categories of antimicrobial agents for the treatment of bacterial infectious diseases in humans, domestic animals, and pets. One of the hottest research areas right now is discovering alternatives or enhancers for existing conventional antibiotics. Researchers have found the antibacterial characteristics of mesenchymal stem cells(MSCs). Theoretically, MSCs have the potential to be developed as an effective means for the treatment of bacterial infectious diseases. This paper reviews the research progress in the mechanisms underlying the effects of MSCs on bacterial survival and in the possible impacts of antibiotics on MSCs functions, in hoping to provide references for further clarifying the antibacterial action mechanisms of MSCs and exploring the potential of MSCs as a novel means for therapy of bacterial infectious diseases.