银杏二萜内酯葡氨注射液对缺血性脑卒中患者神经功能及不良反应发生率的影响

Effects of Ginkgo diterpene lactone meglumine injection on nerve function and incidence of adverse reactions in patients with ischemic stroke

目的探究银杏二萜内酯葡氨注射液对缺血性脑卒中患者神经功能及不良反应发生率的影响。方法回顾性分析2019年2月至2020年2月本院收治的100例缺血性脑卒中患者的临床资料,根据治疗方案不同分为对照组和观察组,每组50例。对照组采用常规西医治疗,观察组采用银杏二萜内酯葡氨注射液联合常规西药治疗。比较两组治疗前及治疗2周后血液流变学、神经功能缺损评分(NIHSS)及不良反应发生情况。结果治疗前,两组血浆黏度、纤维蛋白原、血小板聚集指数、NIHSS评分比较差异无统计学意义;治疗2周后,两组血浆黏度、纤维蛋白原、血小板聚集指数及NIHSS评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论缺血性脑卒中患者采用银杏二萜内酯葡氨注射液治疗能改善血液流变学,预防血栓形成,促进神经功能恢复,且安全性较高。

Objective To investigate the effect of ginkgo diterpene lactone meglumine injection on nerve function and incidence of adverse reactions in patients with ischemic stroke.Methods The clinical data of 100 patients with ischemic stroke admitted to our hospital from February 2019to February 2020 were retrospectively analyzed,they were divided into control group and observation group according to different treatment plans,with 50 cases in each group.The control group was treated with conventional western medicine,while the observation group was treated with ginkgo diterpene lactone meglumine injection combined with conventional western medicine.Hemorheology,neurological deficit score(NIHSS)and adverse reactions were compared between the two groups before treatment and after 2 weeks of treatment.Results Before treatment,there was no significant difference in plasma viscosity,fibrinogen,platelet aggregation index and NIHSS score between the two groups;after 2 weeks of treatment,plasma viscosity,fibrinogen,platelet aggregation index and the NIHSS scores in two groups lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions between the two groups was not statistically significant.Conclusion The treatment of ischemic stroke patients with ginkgo diterpene lactone glucosamine injection can improve hemorrheology,prevent thrombosis,and promote the recovery of nerve function,and it is safe.