卵巢低反应患者在微刺激方案中使用不同尿促性腺激素启动剂量治疗效果的比较

Effect contrasts of different human menopausal gonadotrophin initiation dosage during mini-stimulation protocol for poor ovarian response patients

目的分析卵巢低反应(POR)患者在微刺激方案中应用不同尿促性腺激素(HMG)启动剂量的效果。方法选取2019年1月至2020年1月本院收治的接受体外受精胚胎移植助孕治疗的不孕不育症夫妇作为研究对象,共66个周期,根据给予促性腺激素(gonadotropin,Gn)启动剂量的不同分为实验A组(枸橼酸氯米芬片+75 U HMG)43个周期和实验B组(枸橼酸氯米芬片+150 U HMG)23个周期,比较两组Gn总量、Gn使用时间、获卵率、受精率、2PN率、卵裂率及优质胚胎率。结果两组Gn总量比较差异有统计学意义(P<0.05),但两组Gn使用时间比较差异无统计学意义。两组获卵率、受精率、2PN率、卵裂率及优质胚胎率比较差异无统计学意义。结论与150 U的HMG启动剂量相比,POR患者在微刺激方案中采取75 U的HMG启动剂量能获得与其相当的促排卵结局,且能减少患者的Gn使用总量及使用时间,值得临床推广应用。

Objective To analyze the effects of different HMG(human menopausal gonadotrophin)initiation dosage during mini-stimulation protocol for poor ovarian response(POR)patients.Methods Infertile couples who received in vitro fertilization and embryo transfer from January2019 to January 2020 were selected as the research subjects,with a total of 66 cycles.According to different Gn(gonadotropin)initiation dosage,experimental subjects were divided into experimental group A(43 cycles,clomifene citrate tablets+75 U HMG)and experimental group B(23 cycles,CC+150 U HMG).Total Gn contents,Gn usage time,oocyte retrieval rate,fertilization rate,2PN rate,cleavage rate and high quality embryonic rate between the two groups were calculated and compared.Results There was significantly difference in total Gn contents between two groups(P<0.05);but there was no significant difference in Gn usage time between two groups;there was no significant difference in oocyte retrieval rate,fertilization rate,2PN rate,cleavage rate and high quality embryonic rate.Conclusion Compared with 150 U HMG initiation dosage,75 U HMG initiation dosage for POR patients in mini-stimulation protocol can not only achieve the equivalent ovulation induction outcome,but also reduce the total Gn contents and usage time,which is worthly of promotion.