稳定期男性精神分裂症患者吸烟行为与认知功能的关系

Relationship between Cognitive Function and Smoking in Male Patients with Stable Schizophrenia

目的:探讨稳定期男性精神分裂症患者吸烟行为与认知功能的关系。方法:纳入稳定期男性精神分裂症患者112例,其中吸烟组52例,非吸烟组60例。采用阳性和阴性症状量表(PANSS)评定患者的临床精神症状,采用重复性成套神经心理状态测验(RBANS)评定患者的认知功能状况,对结果进行统计分析。结果:吸烟组的一般精神病理症状分和PANSS总分均高于非吸烟组(均P<0.05),吸烟组的即刻记忆、延时记忆和RBANS总分均低于非吸烟组(均P<0.05)。吸烟与即刻记忆(β=-0.233,P=0.009)、延时记忆(β=-0.205,P=0.028)及RBANS总分(β=-0.197,P=0.024)相关。结论:吸烟可能会损伤稳定期男性精神分裂症患者的认知功能,尤其是记忆功能。

Objective:To explore relationship between smoking behavior and cognitive function in male patients with stable schizophrenia.Methods:A total of 112 male patients with stable schizophrenia were enrolled,including 52 patients in smoking group and 60 patients in non-smoking group.Clinical symptoms were assessed by the Positive and Negative Symptom Scale(PANSS),and cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).The results were statistically analyzed.Results:The general psychopathological symptoms scores and PANSS total score in the smoking group were higher than those in the non-smoking group(P<0.05),while the immediate memory score,delayed memory score,and RBANS total score in the smoking group were lower than those in the non-smoking group(P<0.05).Smoking shows a relationship with immediate memory(β=-0.233,P=0.009),delayed memory(β=-0.205,P=0.028),and total RBANS score(β=-0.197,P=0.024).Conclusion:Smoking may impair cognitive function and especially memory function in male patients with stable schizophrenia.