摘要
二甲双胍(MET)是治疗2型糖尿病的一线药物,近年来由于包括胶质母细胞瘤(GBM)在内的高级别胶质瘤的临床有效治疗方案较少,有学者提出MET治疗胶质瘤的可能性,研究表明MET对包含胶质瘤在内的众多实体肿瘤具有抑制作用。为阐清MET抗胶质瘤的确切作用机制,该文对近年来MET抗胶质瘤的相关文献进行综述。
Metformin(MET)is a first-line drug for the treatment of type 2 diabetes. In recent years,due to the lack of effective clinical treatment regimens for high-grade gliomas including glioblastoma(GBM),some scholars have proposed the possibility of MET in the treatment of gliomas,and studies have shown that MET has a considerable inhibitory effect on many solid tumors including gliomas. Therefore,in order to clarify the exact mechanism of MET against glioma,this article reviews the recent articles on the anti-glioma effect of MET.
作者
丁文聪
贺仕清
廖勇仕
DING Wen-Cong;HE Shi-Qing;LIAO Yong-Shi(Department of Neurosurgery,The Affiliated Nanhua Hospital,Hengyang Medical,School,University of South China,Hengyang,Hunan 421002,China;Department of Neurosurgery,The Second Affiliated Hospital,Hengyang Medical,School,University of South China,Hengyang,Hunan 421000,China)
出处
《国际神经病学神经外科学杂志》
2022年第1期51-55,共5页
Journal of International Neurology and Neurosurgery
基金
湖南省自然科学基金面上项目(2018JJ2353)
湖南省科技厅重点研发项目(2017SK2081)。
