内皮糖蛋白在维持性腹膜透析患者腹膜血管新生以及纤维化中作用的研究进展

Research progress on the role of endoglin in peritoneal angiogenesis and fibrosis in maintenance peri⁃toneal dialysis patients

内皮糖蛋白(ENG)是一种同源二聚体跨膜糖基化蛋白,属于转化生长因子β(TGF-β)超家族,主要参与细胞生长分化,调节血管新生以及组织纤维化进程。维持性腹膜透析是终末期肾衰患者主要替代治疗方式之一,腹膜血管新生和纤维化是腹膜超滤衰竭的主要原因,而其具体发生机制尚不明确。本文将对ENG在腹膜血管新生以及纤维化中的相关作用进行综述,并展望其在维持性腹膜透析患者腹膜纤维化中的作用,探索腹膜超滤衰竭的发生机制,为寻求新的治疗靶点提供依据。

Endoglin(ENG)is a homodimeric transmembrane glycosylated protein belonging to the transforming growth factor beta(TGF-β)superfamily,which is mainly involved in cell growth and differentiation,regulation of angio⁃genesis and tissue fibrosis.Maintenance peritoneal dialysis is one of the main alternative treatments for patients with end-stage renal failure.Peritoneal angiogenesis and fibrosis are the main causes of peritoneal ultrafiltration failure,but the ex⁃act mechanism is unclear.This article will review the related role of ENG in peritoneal angiogenesis and fibrosis,and pros⁃pect its role in peritoneal fibrosis in maintenance peritoneal dialysis patients,explore the mechanism of peritoneal ultrafil⁃tration failure,and provide supports for seeking new therapeutic targets.