血红素氧合酶-1在胃肠道疾病中的作用研究进展

Role of HO-1 in gastrointestinal diseases

血红素氧合酶-1(hemeoxygenase-1,HO-1)是血红素代谢过程中的限速酶,催化血红素裂解生成等分子的一氧化碳(carbon monoxide,CO)、胆绿素和Fe^(2+)。HO-1是一种公认的保护剂,具有抗炎、抗氧化的作用,并参与调控细胞增殖、凋亡、自噬等重要生命过程,对各种不同组织的创伤均具有保护作用。多项研究显示,HO-1在非甾体抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)相关性消化道损伤、炎症性肠病(inflammatory bowel disease,IBD)、肠缺血再灌注损伤、消化道肿瘤、胃瘫等多种消化道疾病中均有适应性表达,并起到保护胃肠组织和细胞的重要作用。本文就HO-1在消化道疾病防治中的作用及机制研究进行综述。

Hemeoxygenase-1(HO-1)is a rate-limiting enzyme in heme metabolism,which cleaves heme into equimolar quantities of carbon monoxide(CO),biliverdin and Fe^(2+).HO-1 is a recognized protective agent,which has anti-inflammatory and antioxidant effects and participates in the regulation of cell proliferation,apoptosis,autophagy and other important life processes,and plays a protective role in various tissue injuries.Multiple studies have shown that HO-1 plays an important role in protecting gastrointestinal tissues and cells and has adaptive expression in a variety of gastrointestinal diseases including non-steroidal anti-inflammatory drugs(NSAIDs)related gastrointestinal injury,inflammatory bowel disease disease(IBD),intestinal ischemia-reperfusion injury,gastrointestinal tumor,gastroparesis.We reviewed the role and mechanism of HO-1 in the prevention and treatment of gastrointestinal diseases.