奥美拉唑+甲硝唑分别联合克拉霉素与阿莫西林对慢性胃炎伴消化性溃疡患者Hp清除率的影响

Effects of Omeprazole and Metronidazole Respectively Combined with Clarithromycin and Amoxicillin on Hp Clearance Rate in Patients with Chronic Gastritis Complicated with Peptic Ulcer

目的观察奥美拉唑及甲硝唑分别联合克拉霉素与阿莫西林对慢性胃炎伴消化性溃疡患者幽门螺杆菌(Hp)清除率的影响。方法选取2016年11月至2018年11月我院收治的100例慢性胃炎伴消化性溃疡患者为对象,按照随机数字法为对照组(n=50)和观察组(n=50),对照组给予奥美拉唑及甲硝唑联合阿莫西林治疗,观察组给予奥美拉唑及甲硝唑联合克拉霉素治疗,比较两组临床疗效、Hp清除率、不良反应发生率及1年复发率。结果观察组有效率高于对照组(92.00%vs 72.00%,P<0.05);观察组Hp清除率高于对照组(94.00%vs 76.00%,P<0.05);观察组不良反应发生率低于对照组(8.00%vs 24.00%,P<0.05);观察组复发率低于对照组(4.00%vs 16.00%,P<0.05)。结论奥美拉唑+甲硝唑联合克拉霉素治疗慢性胃炎伴消化性溃疡患者疗效显著,可提高Hp清除率,且安全性较高。

Objective To observe the effects of omeprazole and metronidazole respectively combined with clarithromycin and amoxicillin on Helicobacter pylori(Hp)clearance rate in patients with chronic gastritis complicated with peptic ulcer.Methods A total of 100 patients with chronic gastritis and peptic ulcer treated in the hospital between November 2016 and November 2018 were selected as the subjects.They were divided into control group(n=50)and observation group(n=50)by the random number method.The control group were treated with omeprazole and metronidazole combined with amoxicillin,and the observation group were treated with omeprazole and metronidazole combined with clarithromycin.The clinical efficacy,Hp clearance rate,incidence of adverse reactions and one-year recurrence were compared between the two groups.Results The effective rate and Hp clearance rate of the observation group(92.00%and 94.00%)were higher than those of the control group(72.00%and 76.00%)(P<0.05).The incidence rate of adverse reactions and recurrence rate(8.00%and 4.00%)were lower than those in the control group(24.00%and 16.00%)(P<0.05).Conclusion Omeprazole and metronidazole combined with clarithromycin is markedly effective in treating chronic gastritis with peptic ulcer,and it can improve the Hp clearance with high safety.