基于颅内MRI检查分析抑郁程度与老年脑白质病变部位的关系

Relationship between Depression and Locations of White Matter Lesions in Elderly Patients based on Intracranial MRI

目的分析颅内MRI检查分析抑郁程度与老年脑白质病变部位的关系。方法选取医院2017年4月至2021年4月收治的老年脑白质病变患者150例作为研究对象,按照HAMD评分结果将其分成轻度组、中度组、重度组,例数分别为50例、48例、52例,均接受MRI检查。比较三组患者脑白质病灶部位、病变程度、脑白质病变体积及相关性。结果轻度组、中度组、重度组患者的脑白质病变部位皮质、皮质下白质、基底节和内囊、丘脑、脑干、小脑部位病变率差异比较无统计学意义(P>0.05)。三组患者脑白质病变程度差异比较有统计学意义(P<0.05)。重度组患者重度病变率最高,其次是中度组、轻度组。轻度组患者轻度病变率最高,其次是中度组、重度组。三组患者脑白质病变体积差异比较有统计学意义(P<0.05),由大到小依次是重度组、中度组、轻度组。三组患者MRI检查无抑郁无相关性(P>0.05),轻度、中度、重度均有相关性(P<0.05)。结论MRI既能反映老年脑白质病变患者的病变部位、体积,又能评定抑郁程度,建议使用。

Objective To investigate the relationship between depression and locations of white matter lesions in elderly patients based on intracranial MRI.Methods 150 elderly patients with white matter lesions in our hospital from April 2017 to April 2021 were enrolled,and were assessed by Hamilton Depression Scale(HAMD)and MRI examinations.Patients were divided into three groups according to scores,mild group(n=50),moderate group(n=48)and severe group(n=52).Then the location,degree and volume of white matters were recorded,and the correlations were also analyzed.Results The rate of lesions located at cortex,subcortical area,basal ganglia,internal capsule,thalamus,brainstem and cerebellum had no significant difference among three groups(P>0.05).The degree of white matter lesions had significant difference among three groups(P<0.05).The severe lesion rate was the highest in severe group,followed by moderate group and mild group(P<0.05).The lesion volume was the largest in severe group,followed by moderate group and mild group,with statistic difference(P<0.05).MRI examinations had no correlation with non-depression(P>0.05),while had significant correlations with mild,moderate and severe depressions(P<0.05).Conclusion MRI can reflect lesion location and volume of elderly patients with white matter lesions,which can also assess the depression degree,so it is recommended to application.