^(18)F-NaF PET/CT、^(18)F-FDG PET/CT及MRI对鼻咽癌患者颅底骨质受侵及骨转移的评估价值比较

Comparison of Evaluated Value of ^(18)F-NaF PET/CT,^(18)F-FDG PET/CT,and MRI on Skull base Invasion and Bone Metastasis in Patients with Nasopharyngeal Carcinoma

目的分析;氟-氟化钠(^(18)F-Na F)正电子发射计算机断层显像/电子计算机X射线断层扫描技术(PET/CT)、;氟-脱氧葡萄糖(^(18)F-FDG)PET/CT及磁共振成像(MRI)对鼻咽癌患者颅底骨质受侵及骨转移的评估价值。方法收集48例经病理证实为鼻咽癌患者的临床资料,入院后均接受^(18)F-Na F PET/CT、^(18)F-FDG PET/CT、MRI检查,统计不同检查方法检出颅底骨质破坏及骨转移情况,比较三种方式对鼻咽癌诊断效能。结果^(18)F-Na F PET/CT、MRI诊断鼻咽癌颅底骨质受侵、骨转移效能均优于^(18)F-FDG PET/CT(P<0.05),但^(18)F-Na F PET/CT、MRI比较差异无统计学意义(P>0.05);骨质侵犯病灶分布:^(18)F-Na F PET/CT、^(18)F-FDG PET/CT、MRI检出颅底骨质受侵部位以枕骨斜坡受侵为主,检出率分别为84.62%(22/26)、69.23%(;/26)、80.77%(21/26);骨转移病灶:以椎体分布为主,其次为胸肋与骨盆。结论^(18)F-Na F PET/CT、MRI对鼻咽癌颅底骨质受侵、骨转移诊断效能优于^(18)F-FDG PET/CT。

Objective To analyze the evaluated value of ^(18)F-fluorine-sodium fluoride(^(18)F-NaF)positron emission tomography/computer tomography(PET/CT),^(18)F-fluorodeoxyglucose(^(18)F-FDG)PET/CT and magnetic resonance imaging(MRI)on skull base invasion and bone metastasis in patients with nasopharyngeal carcinoma.Methods The clinical data of 48 patients with pathologically confirmed nasopharyngeal carcinoma were collected.All patients underwent ^(18)F-NaF PET/CT,^(18)F-FDG PET/CT,and MRI after admission.The detection of skull base bone destruction and bone metastasis were counted by different examination methods,and the diagnostic efficacy of three methods on nasopharyngeal carcinoma was compared.Results The efficacies of ^(18)F-NaF PET/CT and MRI were superior to those of ^(18)F-FDG PET/CT in the diagnosis of skull base invasion and bone metastasis of nasopharyngeal carcinoma(P<0.05),but there were no statistically significant differences between ^(18)F-NaF PET/CT and MRI(P>0.05).The distribution of bone invasion lesions:skull base invasion site detected by ^(18)F-NaF PET/CT,^(18)F-FDG PET/CT,and MRI was mainly affected by occipital slope invasion,and the detection rates were 84.62%(22/26),69.23%(;/26),and 80.77%(21/26),respectively.Bone metastasis lesions were predominantly vertebral distribution,followed by thoracic ribs and pelvis.Conclusion The diagnostic efficacies of ^(18)F-NaF PET/CT and MRI are superior to ^(18)F-FDG PET/CT in the diagnosis of skull base invasion and bone metastasis of nasopharyngeal carcinoma.