血清VEGF-C、VEGFR-3水平表达、淋巴管生成与周围型肺腺癌CT表现相关性的研究

Correlation between the Expression Levels of VEGF-C and VEGFR-3,and Lymphangiogenesis and CT Manifestations of Peripheral Lung Adenocarcinoma

目的研究血管生长因子C(VEGF-C)、血管内皮生长因子受体3(VEGFR-3)水平表达、淋巴管生成与周围型肺腺癌CT表现的相关性。方法选取本院2017年2月至2019年4月收治的52例周围型肺腺癌患者作为研究对象,观察肿瘤病灶大小、形态、有无淋巴结转移等征象,分析周围型肺腺癌的CT征象与VEGF-C、VEGFR-3、淋巴管密度(LMVD)关系。结果周围型肺腺癌VEGF-C阳性表达者,肺门、纵隔淋巴结以增大为主、肿瘤多可见“分叶”征和血管“集束”征,淋巴结多发生转移,有肺门、纵隔淋巴结以增大、“分叶”征、血管“集束”征及淋巴结转移者LMVD值更高;VEGFR-3阳性表达者CT征象与VEGF-C阳性表达者相似,但其血管“集束”征以VEGFR-3阴性表达者较多见,“棘突”征以VEGFR-3阳性表达者多见。结论CT检查可有效显示周围型肺腺癌的影像学征象,其CT征象与血清VEGF-C、VEGFR-3水平表达,淋巴管生成具有一定相关性,可有效预测肺癌转移与侵袭。

Objective To investigate the correlation between the expression levels of vascular endothelial growth factor-C(VEGF-C)and vascular endothelial growth factor receptor 3(VEGFR-3)and lymphangiogenesis and CT manifestations of peripheral lung adenocarcinoma.Methods 52 patients with peripheral lung adenocarcinoma treated in our hospital from February 2017 to April 2019 were selected as the research object.The CT signs such as tumor size,shape,and presence or absence of lymph node metastasis were observed,and the relationship between CT signs of peripheral lung adenocarcinoma and VEGF-C,VEGFR-3,and lymphatic vessel density(LMVD)was analyzed.Results In the patients with positive expression of VEGF-C of peripheral lung adenocarcinoma,the hilar and mediastinal lymph nodes were mainly enlarged,and the tumors were often seen with lobular signs and vascular clustering signs.Most lymph nodes metastasize.Patients with hilum,enlarged mediastinal lymph nodes,lobulation signs,vascular clustering signs,and lymph node metastasis had higher LMVD values.The CT signs of patients with VEGFR-3 positive expression were similar to those of patients with VEGF-C positive expression,but the vascular bundle sign was more common in patients with VEGFR-3 negative expression,and the spinous process signs were more common in patients with VEGFR-3 positive expression.Conclusion CT examination can be effectively displayed imaging signs of peripheral lung adenocarcinoma,and CT signs are related to the expression of VEGF-C and VEGFR-3 in serum and lymphangiogenesis,which can effectively predict the metastasis and invasion of lung cancer.