MSCT多期增强征象联合CA199、CA242、NSE对48例肺癌患者诊断效能研究

Diagnostic Value of MSCT Multiphase Enhanced Signs Combined with CA199,CA242,and NSE for Lung Cancer

目的分析多层螺旋CT(MSCT)多期增强征象联合CA199、CA242、NSE对肺癌的诊断价值。方法回顾分析本院2018年12月至2019年9月收治的48例肺癌患者的临床及影像资料,记录所有患者影像征象及血清CA199、CA242、NSE水平,比较不同检查方法对肺癌的诊断价值及不同征象中相关指标水平表达。结果MSCT多期增强扫描检查联合CA199、CA242和NSE检测对肺癌诊断的灵敏度和特异性均显著高于MSCT或血清肿瘤标志物单独检查(P<0.05);48例肺癌患者中表现有坏死空洞12例,有“毛刺”征14例及“深分叶”征16例,其中存在坏死空洞、“毛刺”征以及“深分叶”征肺癌患者其血清CA199、CA242和NSE水平均显著高于无坏死空洞、无“毛刺”征及无“深分叶”征者(P<0.05)。结论MSCT检查中的影像学征象与实验室特异性标志物CA199、CA242和NSE的表达有着密切联系,故将MSCT多期增强扫描检查结合实验室特异性标志物检查相结合对肺癌诊断的临床价值更高。

Objective To analyze the diagnostic value of multiphase enhanced signs of multi-slice spiral CT(MSCT)combined with CA199,CA242 and NSE for lung cancer.Methods The clinical and imaging data of 48 patients with lung cancer treated in our hospital from December 2018 to September 2019 were retrospectively analyzed,and the imaging signs and serum CA199,CA242,and NSE levels of all patients were recorded.The diagnostic value of different examinations for lung cancer and the expression of related indicators in different signs were compared.Results The sensitivity and specificity of MSCT multiphase enhanced scanning combined with CA199,CA242 and NSE detection in the diagnosis of lung cancer were significantly higher than those of MSCT or serum tumor markers alone(P<0.05).In the 48 patients with lung cancer,12 patients had necrotic cavities,14 patients had"burr"signs,and 16 patients had"deep lobulation"signs,in which serum CA199,CA242,and NSE levels were higher than those in patients without necrotic cavities,"burr"signs,and"deep lobulation"signs(P<0.05).Conclusion The imaging signs in MSCT are closely related to the expression of laboratory specific markers CA199,CA242 and NSE.Therefore,the combination of MSCT multi-phase enhanced scanning and laboratory specific markers higher clinical value in the diagnosis of lung cancer.