CT动态增强扫描定量参数评估NSCLC患者靶向治疗临床效果的可行性研究

Feasibility Study of Quantitative Parameters of CT Dynamic Contrast-Enhanced Scanning to Evaluate the Clinical Effects of Targeted Therapy in Patients with NSCLC

目的使用CT动态增强扫描定量参数对NSCLC患者靶向治疗临床效果进行评估,旨在探讨其可行性。方法选取本院2016年3月至2019年5月收治的82例NSCLS患者的临床资料,所有患者均在本院进行靶向治疗。对患者CT图像进行分析,根据RECIST实体瘤疗效果判断标准对82例患者近期治疗效果进行评价,分为缓解组和未缓解组,分别为48例、34例。比较两组患者治疗前后增强扫描参数的变化。结果缓解组治疗后灌注值和PH值明显降低,未缓解组明显升高(P<0.05),两组M/A、Tp(s)值比较差异无统计学意义(P>0.05)。根据患者治疗前后灌注值、PH值的差异,将其分为治疗后降低组和升高组。治疗后灌注值、PH值降低组缓解有效率高于升高组(χ^(2)分别为6.697、3.979,P<0.05)。结论使用CT动态增强扫描定量参数评估NSCLC患者靶向治疗临床效果可行性高,可对早期治疗效果进行判断。

Objective In this paper,we used the quantitative parameters of CT dynamic enhanced scan to evaluate the clinical effects of targeted therapy in patients with NSCLC,in order to explore its feasibility.Methods The clinical data of 82 patients with NSCLS who were admitted to our hospital from March 2016 to May 2019 were selected.All patients were treated with targeted therapy in our hospital.CT images of patients were analyzed,and the short-term therapeutic effects of 82 patients were evaluated according to the criteria of treatment of RECIST solid tumor.They were divided into remission group and non-remission group,48 cases and 34 cases respectively.The parameter changes of the enhanced scan before and after treatment were compared between the two groups.Results The perfusion value and PH of the remission group significantly decreased after treatment,and perfusion value and PH of the non-remission group significantly increased(P<0.05).There was no significant difference in M/A and Tp(s)between the two groups(P>0.05).According to the difference of perfusion value and PH value before and after treatment,the patients were divided into the reduced group and the elevated group after treatment.After treatment,the mitigation effective rate of perfusion value and PH value in the reduced group was higher than that of the elevated group(χ^(2)=6.697,χ^(2)=3.979,P<0.05).Conclusion The feasibility that the quantitative parameters of CT dynamic enhanced scan are used to evaluate the clinical effects of targeted therapy in patients with NSCLC is high,and the early treatment effect can be judged through the parameters.