摘要
骨质疏松症是以骨强度下降和骨折风险增加为特征的常见骨骼疾病,微小RNA(microRNA,miRNA)在骨质疏松症的病因及分子生物学机制中扮演着重要角色,明确其功能及作用机制将为骨质疏松症的诊断与防治提供新的思路与靶点。本文对microRNA-133a在骨质疏松中的相关作用机制进行综述,系统阐述microRNA-133a与骨质疏松症发生的对应关系及其在成骨和破骨分化中的具体作用机制,以期为临床治疗和基础研究提供一定的借鉴。
Osteoporosis is a common bone disease characterized by decreased bone strength and increased risk of fracture.MicroRNA plays an important role in the etiology and molecular biological mechanisms of osteoporosis.Clarifying its function and mechanism of action will provide new ideas and targets for the diagnosis,prevention,and treatment of osteoporosis.In this article,the relevant mechanisms of microRNA-133a in osteoporosis will be reviewed,and the corresponding relationship between microRNA-133a and the occurrence of osteoporosis as well as the specific mechanisms of microRNA-133a in osteoblast and osteoclast differentiation will be systematically elaborated,with a view to providing certain reference for clinical treatment and basic research.
作者
万里甫
王刚
张月雷
WAN Li-fu;WANG Gang;ZHANG Yue-lei(Department of Orthopaedics,The First Affiliated Hospital of Anhui Medical University,Hefei 230000,China)
出处
《中华骨质疏松和骨矿盐疾病杂志》
CSCD
北大核心
2021年第6期668-673,共6页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
国家自然科学基金(81702134)
安徽医科大学校基金临床科学基金(2020xkj183)。
