恩拉霉素提取工艺研究

Extraction Technology of Enramycin

为优化恩拉霉素提取工艺,以70%甲醇溶液为提取剂,提取恩拉霉素,经过浓缩、脱色、结晶、重结晶,制备高含量恩拉霉素产品。得到最佳提取工艺条件是:浸提pH3.5~4.0,浸提温度30℃,三次浸提时间1 h,一次浸提料液比1∶7,二次浸提料液比1∶3,三次浸提料液比1∶3,活性炭用量是浓缩液体积的1.0%~1.5%,粗精粉重结晶得到纯品,含量97%。

To optimize extraction technology of Enramycin,70%methanol solution was used to extract Enramycin,and then was concentrated,decolorized,crystallized,recrystallized.The active pharmaceutical ingredient(API)was produced.The optimized extraction technological conditions were pH 3.5~4.0,temperature 30℃,extraction time1h,three extraction process ed with material-liquid ratios 1∶7,1∶3,1∶3,1.0%~1.5%ratio of activated carbon/concentrated solution,recrystallized once.The product of Enramycin was 97%.