胆汁酸膜受体TGR5在胆道疾病中的研究进展

Research advances in the bile acid membrane receptor TGR5 in biliary tract diseases

TGR5是一种胆汁酸激活的G蛋白偶联受体,在胆道系统生理及病理过程中发挥着重要作用。本文简述了在正常生理情况下,TGR5在肝脏及胆管中的正常表达情况,及发挥调节胆汁酸分泌、代谢,细胞保护作用等功能。归纳了在病理生理情况下,TGR5表达及功能的变化通过炎症反应、细胞增殖、凋亡等途径来影响疾病的发生与发展的机制。TGR5可能是未来治疗胆道疾病的潜在靶点。

TGR5 is a bile acid-activated G protein-coupled receptor and plays an important role in the physiological and pathological processes of the biliary system.This article describes the normal expression of TGR5 in the liver and bile duct under normal physiological conditions and its functions including the regulation of bile acid secretion and metabolism and cytoprotection.This article also summarizes the changes in the expression and function of TGR5 under pathophysiological conditions and the mechanism of TGR5 in affecting the development and progression of biliary tract diseases through inflammatory response and cell proliferation and apoptosis.TGR5 may be a potential target for the treatment of biliary tract diseases in the future.