白细胞介素-35在非感染性葡萄膜炎中的研究进展

Research advances in interleukin-35 for the treatment of non-infectious uveitis

白细胞介素(IL)-35是IL^(-1)2家族的新成员。它在多种自身免疫性疾病、器官移植和肿瘤中发挥作用,是一类具有重要治疗前景的抗炎细胞因子。许多研究显示IL-35参与多种非感染性葡萄膜炎的发生、发展。本文就IL-35的结构与来源、生物学功能及IL-35在自身免疫性葡萄膜炎中的研究进展进行综述。

Interleukin-35(IL-35) is the recently identified member of the IL^(-1)2 family. It plays a role in a variety of autoimmune diseases, organ transplantation and tumors, as a kind of anti-inflammatory cytokine with important therapeutic prospects. Many studies have shown that IL-35 is involved in the occurrence and development of the non-infectious uveitis. This paper reviews the structure, source, and biological function of IL-35, as well as research advances in the treatment of autoimmune uveitis by IL-35.