自血疗法联合308 nm准分子激光治疗局限性白癜风疗效观察

Efficacy Observation of Autohemotherapy Combined with 308 nm Excimer Laser for Localized Vitiligo

目的观察自血疗法联合308 nm准分子激光治疗局限性白癜风的临床疗效。方法将90例白癜风患者随机分为自血组、火针组和基础组,每组30例。基础组选用308 nm准分子激光治疗,联合局部外用1%的他克莫司软膏和口服驱白巴布期片;火针组在基础组的治疗基础上联合火针治疗;自血组在基础组的治疗基础上联合自血注射治疗。分别记录患者治疗前后的皮损面积、白斑色素积分和皮肤病生活质量指数(DLQI),并比较3组临床疗效。结果自血组与火针组的总有效率比较,差异有统计学意义(P<0.05);自血组与基础组比较,差异有统计学意义(P<0.01);火针组与基础组比较,差异无统计学意义(P>0.05)。3组治疗后白斑面积、白斑色素积分和DLQI评分优于治疗前(P<0.05)。自血组白斑面积、白斑色素积分和DLQI评分优于火针组和基础组(P<0.05,P<0.01);火针组白斑色素积分和DLQI评分优于基础组(P<0.05,P<0.01)。结论自血疗法联合308 nm准分子激光治疗局限性白癜风的临床疗效、缩小局限性白癜风患者的白斑面积、改善色素积分和提高生活质量优于火针联合308 nm准分子激光及基础治疗。

Objective To observe the clinical efficacy of autohemotherapy plus 308 nm excimer laser in treating localized vitiligo.Method Ninety vitiligo patients were randomized into an autohemotherapy group,a fire needle group,and a basic group,with 30 cases in each group.The basic group was treated with 308 nm excimer laser combined with external application of 1%Tacrolimus ointment and oral administration of Qu Bai Ba Bu Qi tablets.Based on the intervention in the basic group,the fire needle group was given fire needle therapy,and the autohemotherapy group was offered autoblood injection.Before and after the intervention,the skin lesion size,vitiligo pigment score,and dermatology life quality index(DLQI)score were recorded.The clinical efficacy was also compared among the three groups.Result There was a significant difference in the total effective rate between the autohemotherapy group and fire needle group(P<0.05),the difference between the autohemotherapy and basic groups was statistically significant(P<0.01),but the difference between the fire needle and basic groups was statistically insignificant(P>0.05).After the treatment,the vitiligo size,pigment score,and DLQI score improved in all three groups(P<0.05).The vitiligo size,pigment score,and DLQI score were better in the autohemotherapy group than in the fire needle and basic groups(P<0.05,P<0.01),and the pigment score,DLQI score was better in the fire needle group than in the basic group(P<0.05,P<0.01).Conclusion Compared with fire needle therapy plus 308 nm excimer laser or the basic treatment,autohemotherapy plus308 nm excimer laser can produce more significant clinical efficacy and better effects in reducing the skin lesion size,improving pigment score,and enhancing the quality of life in treating localized vitiligo.