摘要
Krüppel样因子15(KLF15)是包含锌指结构域的Krüppel样因子(KLF)家族中的重要一员。研究显示KLF15通过调控各种信号传导通路以及能量代谢在心血管疾病中发挥重要作用。例如KLF15可以通过影响肌细胞增强因子2(MEF2)或转化生长因子β(TGF-β)等发挥抗心肌重塑的作用,且KLF15是维系室性心律失常与昼夜节律关系的关键因子。本文综述了KLF15在心脏中的生理病理作用以及其在心血管疾病中的最新研究进展。
Krüppel-like factor 15(KLF15)is a critical member of Krüppel-like factor(KLF)family containing zinc finger.Studies have shown that KLF15 plays an important role in regulating various signal transduction pathways and energy metabolism.KLF15 can play an anti-myocardial remodeling role by affecting myocyte enhancer factor 2(MEF2),transforming growth factorβ(TGF-β)and so on.In addition,KLF15 is the key factor to maintain ventricular arrhythmia and circadian rhythm.This paper reviews the physiological and pathological role of KLF15 in the heart and the latest research progress in cardiovascular diseases.
作者
毛帅
吴钢
MAO Shuai;WU Gang(Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China;Cardiovascular Research Institute,Wuhan University,Wuhan,Hubei 430060,China;Hubei Key Laboratory of Cardiology,Wuhan,Hubei 430060,China)
出处
《中国动脉硬化杂志》
CAS
2022年第4期352-356,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81870301)。
