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Nano drug delivery systems improve metastatic breast cancer therapy

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摘要 Despite continual progress in the technologies and regimens for cancer therapy,the treatment outcome of fatal metastatic breast cancer is far from satisfactory.Encouragingly,nanotechnology has emerged as a valuable tool to optimize drug delivery process in cancer therapy via preventing the cargos from degradation,improving the tumor-targeting efficiency,enhancing therapeutic agents’retention in specific sites,and controlling drug release.In the last decade,several mechanisms of suppressing tumor metastasis by functional nano drug delivery systems(NDDSs)have been revealed and a guidance for the rational design of anti-metastasis NDDSs is summarized,which consist of three aspects:optimization of physiochemical properties,tumor microenvironment remodeling,and biomimetic strategies.A series of medicinal functional biomaterials and anti-metastatic breast cancer NDDSs constructed by our team are introduced in this review.It is hoped that better anti-metastasis strategies can be inspired and applied in clinic.
出处 《Medical Review》 2021年第2期244-274,共31页 医学评论(英文)
基金 National Natural Science Foundation of China(81871471,81630052,81521005,and 81690265) Natural Science Foundation of Shanghai(19ZR1479900) International Partnership Program of CAS(153631KY SB20190013) Natural Science Foundation of Shandong(ZR2019ZD25) Special Research Assistant Project of CAS,China Postdoctoral Science Foundation(2020M681428) Shanghai Post-doctoral Excellence Program are gratefully acknowledged for financial support.
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